Download PDF by Balz Frei: Natural antioxidants in human health and disease

By Balz Frei

ISBN-10: 0122669754

ISBN-13: 9780122669750

This ebook serves as a complete assessment of the present clinical wisdom at the overall healthiness results of nutritional and supplemental antioxidants (such as supplementations C and E). Chapters combine info from uncomplicated study and animal reports, epidemiologic experiences, and medical intervention trials.
The renowned media has taken nice curiosity in antioxidants, with a number of articles emphasizing their function in combating illness and the prospective slowing of the getting older approach. those antioxidant supplements can be vital in combating not just acute deficiency indicators, but additionally continual issues similar to center affliction and sure sorts of melanoma. This booklet, accordingly, is not just for scientists and medical professionals, but additionally for well-being writers, reporters, and knowledgeable lay people.
The textual content makes a speciality of numerous human stipulations for which there's now sturdy medical facts that oxidation is a crucial etiological part. particularly, antioxidants could hinder or decelerate the development of: melanoma, heart problems, Immune method problems, Cataracts, Neurological issues, Degeneration as a result of the getting older procedure.

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A. (1984). Free radicals in autoxidation and in aging. Part I. Kinetics of the autoxidation of linoleic acid in SDS micelles: Calculations of radical concentrations, kinetic chain lengths, and the effects of vitamin E. Part II. The role of radicals in chronic human diseases and in aging. In "Free Radicals in Molecular Biology, Aging and Disease" (D. Armstrong, R. S. Sohal, R. G. Cutler, and T. F. ), pp. 13-41. Raven, New York. Pryor, W. A. (1986). Oxy-radicals and related species: their formation, lifetimes, and reactions.

34, 1745-1753. Markey, C. , Weller, P. , and Marnett, L. 1. (1987). Quantitative studies of hydroperoxide reduction by prostaglandin H synthase: Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities. J. Bioi. Chem. 262, 6266-6279. Marietta, M. A. (1989). Nitric oxide: Biosynthesis and biological significance. Trends Biochem. Sci. 14, 488-492. Marnett, L. 1. (1987). Peroxyl free radicals: Potential mediators of tumor initiation and promotion. Carcinogenesis 8, 1365-1373.

Although not formally terminating the radical chain, the phenoxyl radicals, tend to be less reactive in a biological matrix than are peroxyl radicals, and the process of peroxidation is slowed. Evidence for the reduction of the tocopheroxyl radical by ascorbate (vitamin C) or GSH in vitro has been reported, but efforts to determine the possible significance of redox cycling regeneration of vitamin E in vivo thus far have been inconclusive (Liebler, 1993). The tocopheroxyl radical can transfer another electron to a lipid peroxyl radical or add a peroxyl radical to generate the corresponding 8a-(alkyldioxy)tocopherones in reactions that represent true terminations of the radical chains (Liebler, 1993).

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Natural antioxidants in human health and disease by Balz Frei

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