Myelination and Demyelination: Implications for Multiple by Seung U. Kim (auth.), Seung U. Kim (eds.) PDF

By Seung U. Kim (auth.), Seung U. Kim (eds.)

ISBN-10: 146128077X

ISBN-13: 9781461280774

ISBN-10: 1461307775

ISBN-13: 9781461307778

In June 1987, neurobiologists, immunologists, molecular biologists, virologists and neurologists from numerous international locations met in Vancouver to debate fresh advances of relevance to a number of sclerosis. The symposium used to be part of the twenty second Canadian Congress of Neurological Sciences assembly and used to be subsidized by way of cash from the a number of Sclerosis Society of Canada and the clinical study Council of Canada. The displays coated 5 significant issues: simple neurobiology, molecular biology, the function of viruses in demyelination, immune functionality and disorder in a number of sclerosis, and medical magnetic resonance imaging reviews. It used to be heartening to notice that scientists from numerous diverse disciplines have been training a typical end-point: the knowledge and therapy of a number of sclerosis. during this e-book, audio system on the symposium have each one awarded a bankruptcy in their findings and discussions. furthermore, a few non-participants on the symposium were invited to put up chapters so as to provide this quantity a extra entire scope. it's was hoping that the reader will locate this e-book an invaluable reference for numerous topics of curiosity to a number of sclerosis. In final, i want to thank the subsequent for his or her support and help: the a number of Sclerosis Society of Canada and the clinical study Council of Canada for his or her monetary help; the individuals of this e-book for his or her manuscripts; Dr. A. Eisen, Mrs. okay. Eisen, Mrs. P. Bodnarchuk and Mrs. M. Kim for his or her efforts in making plans and organizing the symposium; and Ms. Catherine Schikowski for her secretarial guidance. Seung U. Kim, M.D. Ph.D.

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Extra resources for Myelination and Demyelination: Implications for Multiple Sclerosis

Example text

In disease states where cells are lost, such as for oligodendrocytes in multiple sclerosis, induction of mitosis may achieve a critical number of the same cell type to enable restoration of function. This aim is not without clinical support. In multiple sclerosis, proliferation of oligodendrocytes, albeit limited in its extent, has already been reported in the relatively normal white matter adjacent to disease plaques (60). What is therefore required are stimuli to enhance this limited regenerative capacity already observed.

This cellular proliferation, called "myelination gliosis", is accompanied by changes in glial cell morphology (14) as well as the accumulation of the lipid components of myelin (15, 16). This pattern suggests that the production of substances which promote oligodendrocyte precursor migration, proliferation and subsequent maturation occurs locally around specific axon tracts to be myelinated. Current evidence from studies of rat optic nerve cultures suggests that type I or protoplasmic astrocytes secrete a factor(s) which promotes oligodendrocyte precursor proliferation (17, 18, 19).

Dissociated cells were passaged through a nylon mesh of 100 um pore size, mixed with Percoll (Pharmacia) (final concentration of 30% Percoll) and centrifuged at 15000 rpm for 25 minutes. Oligodendrocytes and astrocytes, floating between an upper myelin layer and a lower erythrocyte layer, were diluted with 3 volumes of HBSS and harvested by centrifugation at 1500 rpm for 10 minutes. The cells were washed twice in HBSS, suspended in feeding medium, and plated onto 9 mm Aclar plastic covers lips coated with 10 ug/ml polylysine (Sigma, approximate molecular weight of 400,000) at a density of 10 4 cells/coverslip.

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Myelination and Demyelination: Implications for Multiple Sclerosis by Seung U. Kim (auth.), Seung U. Kim (eds.)


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