By Seymour Kaufman (auth.), B. W. Agranoff, M. H. Aprison (eds.)
In the Preface to quantity 1, we said: This sequence acknowledges that investigators who've entered neurochemistry from the biochemical culture have a slightly really good view of the mind. Too frequently, interdisci plinary choices are firstly appealing yet prove to recite easy biochemical considera tions. now we have come to think that there are actually sufficiently huge numbers of neurochemists to aid a really good enterprise similar to the current one. we've began with attention of conventional components of neurochemistry which express significant clinical task. we are hoping they're going to serve the neurochemist either for basic interpreting and for specialised details. The reader also will find a way to mirror at the unbridled hypothesis that effects from the disinhibiting results at the writer who has been invited to write down a bankruptcy. We plan sometimes additionally to provide experiences of components now not thoroughly within the area of neurochemistry which we however believe to be sufficiently well timed to be referred to as to the eye of all who use chemical rules and instruments with the intention to greater comprehend the mind. The contributions to the current quantity pursue those pursuits. We think the sequence has set excessive criteria and has endured to uphold them. in keeping with the primary said within the final paragraph of the Preface quantity 1, we comprise during this quantity Koshland's "Sensory reaction in micro organism" (Chapter 5).
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1965). If cytoplasmic tyrosine aminotransferase were playing a major role in phenylalanine transamination, one would expect that the concentrations of phenylalanine in plasma and liver would also decrease in response to steroids. , 1965). , cytoplasmic tyrosine aminotransferase cannot be the enzyme responsible for most of phenylalanine transamination. As will be shown later, if all phenylalanine transamination were mediated by an enzyme the activity of which was elevated fivefold by cortisone, transamination would then account for a sufficient fraction of phenylalanine metabolism so that changes in phenylalanine content should be detectable after steroid administration.
05 ml. 3 mg protein), was added to each tube. 03 mM. The radioactivity in the tyrosine area after incubation with a boiled enzyme control was equivalent to 14 pmol tyrosineihr per mg protein. tg of this fraction was added to each reaction tube assayed. 1 mM. a 22 CHAPTER 1 PKU liver sample. The results of Experiment B (Table 1) ruled out this possibility. The potent and specific tyrosine hydroxylase inhibitor, 3-iodotyrosine, inhibited tyrosine formation by only 14%. Since rat liver phenylalanine hydroxylase is not inhibited at all by this concentration of iodotyrosine, it was concluded that no more than 14% of the hydroxylation that was observed could have been due to tyrosine hydroxylase.
5-fold), and in two patients with hyperphenylalaninemia (two- to fivefold). From their results, these workers concluded that the effect of added cofactor on the hydroxylase activity could serve as an important criterion for the classification of various forms ofPKU. , 1973). , 1973), the formation of tyrosine that was detected by Grimm and co-workers in classical PKU was probably not due to the phenylalanine-hydroxylase-catalyzed conversion of phenylalanine to tyrosine, but to the proteolytic liberation of tyrosine from proteins that are present in liver extracts.
Advances in Neurochemistry by Seymour Kaufman (auth.), B. W. Agranoff, M. H. Aprison (eds.)