By Gilson Khang, Moon Suk Kim, Hai Bang Lee
Tissue engineering has been famous as providing another strategy to whole-organ and tissue transplantation for diseased, failed, or malfunctioned organs. To reconstruct a brand new tissue through tissue engineering, the next triad elements are wanted: (1) cells that are harvested and dissociated from the donor tissue; (2) biomaterials as scaffold substrates during which cells are connected and cultured, leading to implantation on the wanted web site of the functioning tissue; and (3) progress elements which advertise and/or hinder phone adhesion, proliferation, migration, and differentiation. of those 3 key parts, scaffolds play a severe position in tissue engineering. This well timed ebook makes a speciality of the coaching and characterization of scaffold biomaterials for the applying of tissue-engineered scaffolds. extra importantly, it serves as an experimental guidebook at the standardization of the fabrication approach and characterization of scaffolding expertise.
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Additional info for A Manual for Biomaterials/Scaffold Fabrication Technology
9] Khang G, Kim MS, Min BH, Lee I, Rhee JM, Lee HB. Tissue Eng Reg Med 3: 376–395, 2006.  Seal BL, Otero TC, Panitch A. Mater Sci Eng R 34: 147–230, 2001. qxd 5/17/2007 8:18 PM Page 12 FA 12 Introduction  Thompson RC, Wake MC, Yasemski MJ, Mikos AG. Adv Polym Sci 122: 245–274, 1995.  Khang G, Shin P, Kim I, Lee B, Lee SJ, Lee YM, Lee HB, Lee I. Macromol Res 10: 158–167, 2002.  Leibmann-Vinson A, Hemperly JJ, Guarino RD, Spargo CA, Heidaran MA. ), Tissue Engineering and Biodegradable Equivalents: Scientific and Clinical Applications, Marcel Dekker, New York, 2002.
Qxd 5/14/2007 6:50 PM Page xxix FA List of Contributors Soo Chang Song, PhD Division of Life Science Korea Institute of Science and Technology Seongbuk, Seoul 130-650 Korea Rui A. Sousa, MS 3B’s Research Group — Biomaterials, Biodegradables and Biomimetics University of Minho, Campus of Gualtar Braga 4710-057 Portugal Tao Xu, MS Wake Forest Institute for Regenerative Medicine Wake Forest University Health Sciences Medical Center Boulevard, Winston-Salem NC 27157 USA James J. qxd 5/17/2007 8:18 PM Page 2 FA 2 Introduction It has been recognised that tissue engineering offers an alternative technique to tissue transplantation for diseased or malfunctioned organs.
Nanoelectrospinning of PGA, PLA, PLGA, PCL copolymers, collagen, elastin, etc. has been extensively developed. For example, electrostatic processing can consistently produce PGA fibre diameters at or below 1 µm. By controlling the pick-up of these fibres, the orientation and mechanical properties can be tailored to a specific need of the injured site. 083 g/mL concentration. The optimally electrospun type I collagen nonwoven fabric appeared with an average diameter of 100 ± 40 nm, resulting in biomimicking of fibrous scaffolds (Chapters N–P).
A Manual for Biomaterials/Scaffold Fabrication Technology by Gilson Khang, Moon Suk Kim, Hai Bang Lee